Metformin is a popular drug used to lower blood sugar in patients with type 2 diabetes, especially those who are overweight or obese but have normal kidney function. In addition to its primary indication, metformin is undergoing clinical trials for other diseases in which insulin resistance may be an important factor. According to the pharmacological classification, metformin is an oral glycemic agent from the biguanide group (dimethylbiguanide).
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Today, medications to control diabetes mellitus, among which metformin, recognized by WHO as one of the most effective drugs against type 2 diabetes mellitus, is not the least important, can be purchased not only in a traditional local pharmacy, but also in numerous online pharmacies that offer both the original medicine and its numerous generics. Buying metformin online is a way to save a significant amount and save yourself from finding the necessary medicine in a dosage that suits you by going to a pharmacy in person or even several. Ordering metformin online today is a simple process, no different from purchasing any other medicine or product from an online store like Amazon. When buying metformin online, it is important to pay attention to the dosage of the drug. The most popular are 500 and 1,000 mg. You need to follow your doctor’s recommendations and do not experiment with dosages on your own.
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The dosage and frequency of taking metformin depend on the treatment regimen, the patient’s age and the dosage form used, as well as the indication for which this medicine is used. It should be remembered that metformin is prescribed to control type 2 diabetes mellitus, also known as non-insulin-dependent diabetes, when diet and exercise have failed, and in obese patients. In adults, this medicine is used as monotherapy or in combination with other oral hypoglycemic agents or with insulin, in children aged 10 years and older as monotherapy or in combination with insulin. In addition, metformin is now increasingly used in the treatment of polycystic ovary syndrome, non-alcoholic fatty liver disease and precocious puberty. These diseases are accompanied by insulin resistance, so metformin may be effective in their treatment. However, to date, these indications are still considered experimental.
The initial dosage of metformin is 500 to 850 mg two to three times a day. Metformin should be taken during meals or immediately after meals. The dosage is adjusted depending on the results of the analysis; this should be done by an endocrinologist. The maintenance dose ranges from 1,500 to 2,000 mg per day, and the maximum dose is 3,000 mg per day. It cannot be taken at one time, but must be divided into two or three doses. 1,000 mg is the most popular dosage of Metformin. It is used not only by those patients who take tablets twice a day, but also by those who find it more convenient to take half a tablet three times a day. If you have been familiar with this medicine for a long time, the dosage of 1,000 mg is the most suitable for you.
Most patients take metformin for a long period of time, up to several years. Some take this medicine for decades, of course, provided that it is well tolerated by the body and the treatment is supervised by a doctor. Due to the fact that this medicine significantly improves the patient’s condition and quality of life, it is practically the most important drug used in the treatment of type 2 diabetes mellitus, if changes in lifestyle and diet are not enough to bring blood sugar under control. Continuous use of medication implies not only a constant positive therapeutic effect, but also constant costs. Purchasing metformin 1000 mg online helps save up to 90% of the cost of the original medicine. Diabetes is a disease that greatly affects many aspects of a patient’s daily life. Ordering metformin online is a way to minimize the impact of this disease on your wallet. If therapy has just started, it is better to opt for a dosage of 500 mg, which helps to more accurately adjust the dosage and allow the body to adapt to this medicine.
Metformin 500 Mg Tablet Buy Online
Despite the fact that metformin tablets at a dosage of 500 mg are usually more expensive than at a dosage of 1,000 mg, when purchasing generics this difference is practically not felt. Quite a few patients prefer this form of medication if their daily dose of metformin is 1,500 mg and they take it in three sittings. In addition, a dosage of 500 mg allows for more flexible adjustment of therapy if the patient has difficulties with tolerating this drug in the body and it is necessary to increase the dosage in small steps, that is, 250 mg.
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Despite the fact that metformin is considered one of the main drugs used in the treatment of type 2 diabetes, this medicine is strongly not recommended to be taken without the recommendation of a doctor. Its uncontrolled use can lead to the development of serious complications and side effects. Despite the absence of absolute contraindications for diseases of the liver, kidneys and heart, patients with even compensated diseases of these organs should pay special attention to consultations with a doctor about their concomitant diseases, because in most cases dose adjustment is necessary. There are also strict contraindications to taking metformin, not all of which patients can determine on their own, as well as restrictions, such as, for example, asymptomatic renal dysfunction. However, a fairly common question is how you can buy metformin without a prescription and whether you can do it online. The fact is that the prescription, at least in the USA, as well as in many other countries, is valid for only 2-3 weeks. What about those patients who take medicine on an ongoing basis and do not want to waste their time and money on frequent visits to the doctor to update the treasured paper? In this case, online pharmacies, which primarily have Indian medicines in their assortment, come to the aid of US residents. These are online pharmacies based in India as well as large international online pharmacies. In most of them, the requirements for providing a prescription there are purely formal, and purchasing this drug over the counter doesn’t present any difficulties.
How Does Metformin Work
The active substance of metformin is metformin hydrochloride, a crystalline substance that is white or almost white in color. It dissolves easily in water. Metformin improves glucose tolerance in patients with type 2 diabetes mellitus by reducing both basal and postprandial plasma glucose levels. Metformin reduces hepatic glucose production, reduces intestinal absorption of glucose, and improves the patient’s sensitivity to insulin by increasing peripheral glucose uptake and utilization. During metformin therapy, insulin secretion remains unchanged, while fasting insulin levels and one-day (daily) plasma insulin response may decrease.
The mechanism of action of metformin is associated with its ability to suppress gluconeogenesis, as well as the formation of free fatty acids and fat oxidation. This medicine increases the sensitivity of peripheral insulin receptors and the utilization of glucose by cells. The pharmacodynamics of insulin in the blood changes under the influence of metformin due to a decrease in the ratio of bound to free insulin and an increase in the ratio of insulin to proinsulin.
Metformin stimulates glycogen synthesis by acting on glycogen synthetase, increases the transport capacity of all types of membrane glucose transporters and delays the absorption of glucose in the intestine.
This drug reduces the level of triglycerides, LDL, VLDL. Metformin improves the fibrinolytic properties of blood by suppressing tissue-type plasminogen activator inhibitor. While taking metformin, the patient’s body weight either remains stable or decreases moderately.
Metformin Side Effects
Metformin doesn’t cause serious side effects in most cases of use. From the digestive system, nausea, vomiting, diarrhea, flatulence, and a feeling of discomfort in the abdomen are possible (usually at the beginning of treatment); in isolated cases – impaired liver function indicators, hepatitis (such phenomena disappear after stopping treatment). On the metabolic side, lactic acidosis is very rarely observed. In this case, discontinuation of treatment is required. From the hematopoietic system, a malabsorption of vitamin B12 may develop. The profile of adverse reactions in children aged 10 years and older is the same as in adults.
If during treatment the patient experiences muscle cramps, indigestion (abdominal pain) and severe asthenia, it should be borne in mind that these symptoms may indicate the onset of lactic acidosis. During treatment, it is necessary to monitor kidney function; Determination of lactate content in plasma should be carried out at least 2 times a year, as well as when myalgia appears. When metformin is used as monotherapy in accordance with the dosage regimen, hypoglycemia, as a rule, doesn’t occur. However, when combined with insulin or sulfonylurea derivatives, there is a risk of developing hypoglycemia. In such cases, particularly careful monitoring of blood glucose concentrations is necessary. During treatment, patients should avoid drinking alcohol due to the risk of developing lactic acidosis.
Metformin Weight Loss
Metformin has a side effect of weight loss. Studies in humans and mice have shown that metformin regulates energy balance through the growth differentiation factor GDF15.
Metformin-induced weight loss is almost exclusively limited to reductions in fat mass, with few changes in lean tissue. At the same time, caloric restriction leads to the loss of both lean and fat tissue.
Metformin has several effects on energy metabolism similar to those of exercise, such as phosphorylation of AMP-activated protein kinase, which is an important regulator of mitochondrial biogenetics, fatty acid oxidation in liver and muscle tissue, glucose transport, insulin secretion and lipogenesis.
GDF15, in addition to its main activating effect on macrophages, reduces food intake by binding to receptors in the central nervous system.
Today, Metformin is often used as a drug for weight correction, especially in people with a hereditary predisposition to type 2 diabetes, but only under the strict supervision of a physician. Metformin is not officially approved as a weight loss drug and should not be taken on a personal initiative without consulting an endocrinologist.
Metformin 500 Mg
The recommended initial dose of Metformin is 500 mg 1 time per day in the evening with meals. After 10-15 days, the dose of the drug must be adjusted based on the concentration of glucose in the blood. Metformin should be taken during or after meals to avoid side effects that affect digestion. Take the tablet with a glass of water.
