Avanafil is a medicine used in the treatment of erectile dysfunction and belongs to the pharmacological group of PDE5 inhibitors. Of the currently known drugs in this group, avanafil is the most recently approved, having received FDA approval in 2012 (link). The brand names by which avanafil is known are represented by the trademarks Stendra and Spedra, which are manufactured by VIVUS Inc. headquartered in California, USA.
Like other PDE5 inhibitors, avanafil has specificity for CGMP-cyclic guanosine monophosphate. After local release of nitric oxide occurs as a result of sexual stimulation, inhibition of PDE5 by avanafil causes an increase in the concentration of cGMP in the cavernous bodies of the penis. This leads to the relaxation of smooth muscles, especially the walls of the arteries, and the flow of blood to the tissues of the penis, thus causing a stronger and longer-lasting erection than usual. The effect of avanafil does not develop in the absence of sexual stimulation. This property unites this medicine with all other drugs from the pharmacological category of PDE-5 inhibitors.
Avanafil Vs. Sildenafil
Both avanafil and sildenafil are the active ingredients of popular drugs used to combat erectile dysfunction, regardless of its etiology. In order to understand which drug is better for you – Stendra or Viagra – you need to understand the main differences between avanafil and sildenafil. First of all, it is worth noting that sildenafil is a more well-studied drug. It has been used all over the world since 1998, and doctors have accumulated a huge database regarding its side effects, the effects of this drug on the male body, its interaction with other drugs, and so on. Avanafil is a significantly younger drug, although it has passed all the necessary laboratory and clinical studies, since it received approval from the FDA, the most picky organization that regulates the circulation of drugs.
Regarding the pharmacokinetics of avanafil and sildenafil, avanafil is absorbed into the blood faster. Thus, it begins to affect erection faster. In addition, this medicine remains in a man’s body longer (up to 6 hours versus 5 in the case of sildenafil) and has a lower risk of noticeable side effects. The principle of action of these drugs is the same. However, while sildenafil takes at least 30 minutes to start working, avanafil starts working within 15-20 minutes. Quite a few patients who have experienced both medications note that avanafil causes fewer side effects, such as dizziness, headache, changes in color vision, and redness of the facial skin. This is due to the fact that avanafil is a more selective medicine; it acts more specifically on the tissues of the penis, which leads to systemic side effects occurring less frequently. In other words, the selectivity of avanafil to the PDE-5 enzyme is higher than the selectivity of sildenafil.
Another aspect that distinguishes avanafil from sildenafil is the extent to which food affects the absorption of these drugs into the blood. From the instructions for using sildenafil, it becomes clear that rich and especially fatty foods can seriously slow down the absorption of sildenafil into the blood, as a result of which its effect on the male body becomes more blurred, and sometimes a man may not feel it very much at all. As for avanafil, this drug shows much less sensitivity to how much and what kind of food a man ate before taking it.
In general, avanafil is usually preferred by those men who have experience taking sildenafil as a more well-known and popular drug, which has a significantly larger number of generics, but who are dissatisfied with the side effects that this drug has on the body. Avanafil is recommended as an alternative to sildenafil for those men who suffer from compensated cardiovascular diseases due to the fact that avanafil has less impact on the cardiovascular system and thus its use is less stressful for such patients.
Avanafil Dosage
To develop the effect of taking avanafil, sexual stimulation or tangible sexual desire is necessary. Without these factors, the medicine will not have any noticeable effect on a man, except for possible mild side effects. By itself, taking an avanafil tablet does not have any effect on libido, since this medicine has nothing to do with hormonal or narcotic drugs, and also does not affect the mechanisms of inhibition and excitation of the central nervous system.
Avanafil is taken orally. The recommended starting dose of 100 mg is taken as needed, approximately 15-30 minutes before planned sexual activity.
Depending on the individual effectiveness and tolerability of the drug, the dose can be increased to a maximum of 200 mg or reduced to 50 mg. The maximum recommended frequency of use is once a day to avoid a cumulative effect.
In patients with mild or moderate hepatic impairment, treatment should begin with the minimum effective dose and adjust it depending on the body’s tolerance of avanafil.
Avanafil Online
Just like all other medications used today in the treatment of erectile dysfunction (primarily oral PDE5 inhibitors), avanafil can be purchased online. Many more people are resorting to this method of purchasing medicines today than even five years ago, because since the beginning of the coronavirus pandemic, online medicine sales have received a serious boost. Online pharmacies have reached a new level of interaction with patients, making the process of placing an order and tracking it by the buyer as simple as possible. Today, men with symptoms of erectile dysfunction can purchase Avanafil online from both U.S. and foreign pharmacies. It should be noted that pharmacies registered in the United States sell only original drugs under the trade names Stendra or Spedra. This is due to the protectionist policy of the United States towards drugs that are being developed in this country. However, even if you purchase a brand-name drug online, pharmacies in most cases offer lower prices for this medicine compared to regular local pharmacies, which do not always stock avanafil because it is not as common a drug as sildenafil or tadalafil.
Avanafil Price
Avanafil, like most other drugs used to normalize potency, cannot be considered cheap. Stendra and Spedra sell for prices starting at $60 per tablet. Thus, if a man wants to have an active sex life, he will be forced to spend at least $1,000 a month. Of course, this amount is influenced by various factors, such as the tax system in a particular state, discounts at pharmacies, coupons, drug dosage and features of the patient’s insurance package. However, in general, this is the price of the medicine. This is more than a substantial amount, which hits the wallet of even a wealthy man.
Fortunately, today there is a way to save up to 80% of the cost of the original medicine, because online pharmacies in India have begun to offer cheap avanafil, namely its generics. So far, even in this country, which is known for its affordable pharmaceuticals, there are not too many options for generics of avanafil, but those that exist are practically no different in price from generics of other drugs in the category of PDE-5 inhibitors, which allows a man to choose between these drugs practically without taking into account their cost.
Avanafil Over The Counter
The easiest way to buy avanafil without a doctor’s prescription is also in Indian online pharmacies, because this country is one of the few whose pharmaceutical legislation is quite formal. If you think that this medicine is right for you and you have carefully studied the instructions for use, then you can order Avanafil online without a prescription from any of the major Indian online pharmacies or those international pharmacies that stock Indian medicines. Although such an action means that you take full responsibility for your health, it does not imply that you have committed any offense. And even if the authorities decided to check some case of purchase of this or that medicine, they would have claims only against the seller, but not against the buyer.
