Priligy is one of the most recognized treatments for premature ejaculation (PE), a condition affecting up to 1 in 3 men at some point in their lives. While it is not physically dangerous, it can have a profound impact on psychological well-being, self-esteem, intimate relationships, and overall quality of life.
Defined by consistent ejaculation within one to two minutes of penetration — often with little or no voluntary control — PE is a distressing condition that leads many men to seek medical solutions. For decades, this problem was underdiagnosed and undertreated due to stigma and lack of awareness.
Enter Priligy (dapoxetine) — the first oral medication specifically designed to treat premature ejaculation in men. Its active ingredient is a short-acting selective serotonin reuptake inhibitor (SSRI) developed not for depression, but uniquely for sexual performance issues.
Unlike traditional SSRIs (like fluoxetine or sertraline), which are taken daily and primarily used for mood disorders, Priligy tablets are taken “on demand”, just a few hours before sexual activity. It is fast-acting, has a short half-life, and offers men a practical, targeted way to regain control over ejaculation.
The approval of dapoxetine (Priligy) in over 50 countries — including the UK, Canada, Australia, and parts of Europe — marked a significant step forward in the pharmacological treatment of PE. Although not yet FDA-approved in the United States, it remains a popular choice internationally and is often available via licensed Priligy pharmacy services in many regions.
This guide offers a deep dive into Priligy tablets: how they work, who can use them, their dosage, effectiveness, safety profile, and how they compare to other sexual health treatments like Viagra. Whether you’re considering Priligy for premature ejaculation yourself or researching on behalf of a partner, this article provides science-backed, easy-to-understand insights.
What Is Priligy and How Does It Work?
Priligy (dapoxetine) is a short-acting selective serotonin reuptake inhibitor (SSRI) specifically developed for the on-demand treatment of premature ejaculation (PE) in adult men. Unlike traditional SSRIs prescribed for depression, Priligy is designed to be taken only when needed — usually 1 to 3 hours before sexual activity.
How Dapoxetine Works
Ejaculation is a process regulated by complex neurochemical interactions in the central nervous system. A key neurotransmitter in this process is serotonin (5-HT), which acts to delay ejaculation. Low serotonin levels are often associated with early climax, while higher levels prolong ejaculation latency.
Dapoxetine works by inhibiting the serotonin transporter (SERT), increasing serotonin concentration at synaptic junctions. This elevated serotonin activity strengthens the delay mechanism in the ejaculatory reflex.
Benefits of This Mechanism Include:
- Prolonged intravaginal ejaculatory latency time (IELT)
- Improved control over ejaculation
- Greater sexual satisfaction
- Reduced emotional distress related to PE
Unlike SSRIs used for mood disorders, dapoxetine:
- Is rapidly absorbed (peak effect in 1–2 hours)
- Has a short half-life (initial: ~1.4 hours, terminal: ~19–22 hours)
- Is quickly cleared from the body, minimizing side effects and risk of accumulation
These pharmacokinetic properties make Priligy tablets ideal for use as needed, rather than on a daily basis.
Scientific Evidence
The clinical effectiveness of Priligy has been confirmed in several large international trials. One of the most referenced is a pooled analysis of five phase III randomized controlled studies involving over 6,000 men globally.
According to this meta-analysis, patients taking dapoxetine 30 mg and 60 mg reported:
- A 2–3x increase in IELT (from ~0.9 min to 2–3+ min)
- Significantly greater perceived control
- Higher sexual satisfaction scores
- Reduced distress and interpersonal difficulties
The study concluded that dapoxetine is an effective and well-tolerated treatment for PE, with most side effects being mild and transient (e.g., nausea, dizziness, headache).
You can read the full study here: https://tau.amegroups.org/article/view/3124/html
This clinical evidence supports the use of dapoxetine as a first-line, on-demand option for men seeking reliable relief from premature ejaculation.
Effectiveness and Clinical Evidence
Is Priligy Effective for Premature Ejaculation?
Yes — clinical studies and patient-reported outcomes consistently show that Priligy (dapoxetine) is effective in delaying ejaculation and improving sexual satisfaction in men diagnosed with premature ejaculation (PE).
As a short-acting selective serotonin reuptake inhibitor (SSRI), Priligy tablets have been shown to increase intravaginal ejaculatory latency time (IELT) and improve perceived control during sexual activity. Unlike traditional SSRIs, which are used daily, Priligy is taken on demand, making it more convenient and better tolerated by most users.
What Do Clinical Trials Show?
The effectiveness of Priligy 30mg and Priligy 60 mg has been demonstrated in multiple Phase III randomized controlled trials involving thousands of patients worldwide.
In a pooled analysis of five such studies, men taking these doses experienced the following improvements:
| Measurement | Placebo | Priligy 30mg | Priligy 60mg |
|---|---|---|---|
| Average IELT (in minutes) | ~0.9 | ~2.0 | ~3.2 |
| Improved control over ejaculation (%) | ~30% | ~60% | ~70% |
| Reduction in personal distress (%) | ~28% | ~56% | ~66% |
| Overall satisfaction with intercourse (%) | ~34% | ~62% | ~73% |
These results confirm that both dosages of Priligy significantly outperform placebo, with 60mg generally offering stronger results — though at a slightly higher risk of side effects.
Real-World Use and Patient Feedback
Beyond clinical trials, many men have shared their personal experiences with Priligy (dapoxetine) on pharmacy websites and public forums. These real-world accounts help provide additional context for how the medication works outside of controlled studies.
One user reported:
“Priligy works for me, but I always get about half an hour of stomach ache after I take it. Once the stomach ache clears up, you’re good to go.”
— User from Reddit discussion
Source: Reddit
These testimonials highlight that while Priligy tablets are effective for many men, experiences may vary. Some report excellent results even from the first use, while others may need dose adjustment or encounter mild side effects such as nausea or abdominal discomfort.
How Quickly Does Priligy Work?
Onset of action occurs within 1 to 3 hours after taking the tablet, making it ideal for planned sexual activity. Its peak effect is typically felt around the 2-hour mark.
Duration of effect ranges from 4 to 6 hours, depending on metabolism, dose, and other factors like hydration and concurrent food intake.
Is Priligy Effective Long Term?
While Priligy does not cure PE, long-term intermittent use has been shown to maintain consistent results in most patients. Unlike daily SSRIs, there is no need to “build up” the effect over weeks, and you can stop or restart use as needed.
Some patients also combine Priligy with behavioral techniques like the stop-start method for longer-term improvements.
Available Dosages of Priligy
Priligy (dapoxetine) is available in several dosages designed to accommodate different levels of premature ejaculation severity and individual tolerance. Choosing the right dose depends on how your body responds to the medication, the intensity of your symptoms, and whether you’ve experienced any side effects at lower doses.
Priligy 30 mg: The Starting Point
The standard starting dose for most men is Priligy 30 mg. It is intended for first-time users who are otherwise healthy and want to test how their body reacts to dapoxetine. Priligy 30 mg is typically effective for men with mild to moderate premature ejaculation and is often well tolerated with fewer side effects than higher doses.
This dose is taken 1 to 3 hours before planned sexual activity, and for many men, it significantly increases intravaginal ejaculatory latency time (IELT) while maintaining a good safety profile.
Priligy 60 mg: For Stronger Effect
If the 30 mg dose does not deliver satisfactory results, and no major side effects are observed, your doctor may recommend Priligy 60 mg. This higher dose is more potent and is usually prescribed to men with severe or lifelong PE who need extended control over ejaculation.
Priligy 60 mg is also taken on demand, about 1–3 hours before sex, and it typically leads to a greater delay in ejaculation compared to the lower dose. However, the risk of side effects such as nausea, dizziness, and headaches is also higher, which is why a dose increase should only be done under medical supervision.
Priligy 30mg vs 60mg: What’s the Difference?
Many patients ask: “What’s the difference between Priligy 30mg vs 60mg?” While both contain the same active ingredient (dapoxetine), the 60 mg dose is twice as strong and has been shown in studies to provide longer IELT and more noticeable control.
| Feature | Priligy 30mg | Priligy 60mg |
|---|---|---|
| Effectiveness | Moderate | High |
| Onset time | 1–3 hours | 1–3 hours |
| Duration of action | ~4 hours | ~5–6 hours |
| Side effects (nausea, etc.) | Less likely | More likely |
| Recommended for | First-time users, mild PE | Moderate to severe PE |
In general, Priligy 30 mg is safer, especially for new users, while Priligy 60 mg is better suited for those who have used the drug before and want longer-lasting or stronger results.
Priligy 90mg: Is It Available?
Some users search for Priligy 90mg, assuming a stronger dose might deliver better results. However, Priligy 90 mg is not an approved or recommended dosage. Taking more than the prescribed maximum of 60 mg per 24-hour period can lead to serious side effects, including:
- Low blood pressure
- Fainting
- Serotonin syndrome
- Irregular heartbeat
If you feel that even 60 mg is not effective, do not self-increase the dose — consult your healthcare provider instead. In some cases, combination therapy with Viagra or behavioral strategies may be a safer, more effective route.
How and When to Take Priligy
The correct administration of Priligy tablets is crucial for achieving maximum benefit with minimal side effects.
- Timing: Take one tablet 1 to 3 hours before anticipated sexual activity.
- Water intake: Always take the tablet with at least one full glass of water (minimum 250 ml) to help prevent dizziness or a drop in blood pressure.
- Food: Priligy can be taken with or without food, although taking it with a light meal may help reduce nausea.
- Posture caution: Avoid lying down immediately after taking the tablet, especially if you feel lightheaded.
- Frequency: Do not take more than one tablet in any 24-hour period.
- No daily use: Priligy is not meant for continuous daily dosing — it should be used on-demand only.
When to Consider Increasing the Dose
If Priligy 30mg does not provide adequate control over ejaculation and side effects are minimal, your healthcare provider may recommend increasing the dose to Priligy 60mg.
However, you should never self-adjust your dosage. The decision to increase to 60 mg must always be made by a licensed medical professional after evaluating your health profile and treatment response.
Who Should Take the Lower Dose (30mg) Permanently?
- Men who respond well to 30mg without needing further improvement
- Those who experience side effects with 60mg
- Individuals with mild to moderate PE symptoms
- Older patients or those taking other medications that may increase sensitivity
Missed Dose: What to Do
Since Priligy is taken on-demand, there is no “regular” schedule. If you forget to take the tablet before sexual activity, simply skip it — do not double the dose later to compensate.
Important Safety Guidelines
Although Priligy (dapoxetine) is a safe and effective treatment for many men, proper use is essential to minimize potential health risks. This section outlines when to avoid the medication, which substances can cause interactions, and how to safely integrate it into your routine.
Who Should NOT Take Priligy
Some medical conditions and medications may make Priligy unsafe. If any of the following apply to you, speak to a healthcare provider before using the medication.
| Do not use Priligy if you have: | Why it matters |
|---|---|
| Moderate or severe liver impairment | Impaired drug clearance; increased risk of side effects |
| History of fainting (syncope) or low blood pressure | Priligy may cause orthostatic hypotension |
| Serious heart conditions (e.g., arrhythmia) | Can increase risk of cardiovascular events |
| Are taking MAOIs, SSRIs, SNRIs, or thioridazine | Can lead to serotonin syndrome or QT prolongation |
| Known hypersensitivity to dapoxetine | May cause allergic reactions (rash, swelling, etc.) |
Medications and Substances That Interact with Priligy
To avoid dangerous interactions, you should not combine Priligy with the following:
| Medication / Substance | Potential Risk When Combined |
|---|---|
| Other SSRIs / SNRIs | Serotonin syndrome, increased CNS effects |
| MAO inhibitors | Severe interaction with serotonin levels |
| Thioridazine | Heart rhythm abnormalities (QT prolongation) |
| Lithium, tramadol, tryptophan, St. John’s Wort | Heightened serotonin-related side effects |
| Erectile dysfunction meds (e.g. Viagra) | Blood pressure drop, dizziness |
| Alcohol | Amplified risk of fainting, dizziness, poor coordination |
Always inform your doctor about all prescription and non-prescription drugs you’re taking.
Alcohol and Priligy
Combining Priligy and alcohol is particularly risky because:
- It increases the chances of fainting or sudden drops in blood pressure
- It worsens dizziness, fatigue, and blurred vision
- It can impair judgment, particularly during intimacy
Recommendation: Avoid drinking alcohol within 6–8 hours of taking Priligy.
Driving and Operating Machinery
Priligy may affect mental alertness and physical coordination, especially during the first few uses.
Continue with caution if you experience:
- Dizziness
- Fatigue or drowsiness
- Blurred vision
Recommendation: Avoid driving, cycling, or using machinery until you know how Priligy affects you personally.
Special Cases: Use with Caution If You Have…
This list outlines conditions that don’t always rule out Priligy but require close monitoring:
- Controlled hypertension or hypotension
- Mild liver or kidney impairment
- History of psychiatric disorders (e.g., bipolar, anxiety)
- Diagnosed cardiovascular risk factors (e.g., diabetes, smoking + hypertension)
In these cases, your doctor may recommend:
- Starting with the 30 mg dose
- Avoiding combination with other medications affecting serotonin
- Monitoring blood pressure and symptoms during initial doses
Storage Instructions
- Store in a cool, dry place at room temperature (15–30°C / 59–86°F)
- Keep out of reach of children
- Do not use after the expiry date on the packaging
Quick Reference Summary
| Factor | Recommendation |
|---|---|
| Starting dose | Priligy 30mg |
| Max dose | Priligy 60mg (under supervision) |
| When to take | 1–3 hours before sex |
| Max frequency | 1 tablet per 24 hours |
| Food interaction | Can be taken with or without food |
| With alcohol? | Avoid |
| Daily use? | No — on-demand only |
Side Effects and Tolerability of Priligy
Like any prescription medication, (dapoxetine) Priligy can cause side effects. Fortunately, most users experience mild and short-term reactions, especially when the medication is taken exactly as prescribed. However, it’s important to understand the possible adverse effects before starting treatment to ensure safe and responsible use.
How Common Are Side Effects?
In clinical studies and real-world use, Priligy side effects are typically described as mild to moderate in severity. Most users tolerate the medication well, especially at the standard 30mg dosage. Adverse effects are often short-lived, resolving within a few hours after administration.
The frequency and intensity of side effects appear to be dose-dependent, meaning that men who take Priligy 60mg are statistically more likely to experience unwanted symptoms than those who stick to Priligy 30mg. However, even at higher doses, the majority of reactions are manageable and do not require stopping treatment.
Commonly reported issues include nausea, dizziness, and headache — with nausea being the most frequently cited side effect in clinical trials. These reactions usually occur shortly after taking the tablet and diminish as the drug is eliminated from the body. In many cases, drinking water, avoiding alcohol, and staying seated during onset help reduce their severity.
Ultimately, most side effects associated with dapoxetine tablets are considered transient, non-severe, and self-resolving, particularly when the medication is used responsibly and according to instructions.
Most Common Side Effects
These side effects were reported by more than 5% of patients in clinical studies:
| Side Effect | Frequency | Notes |
|---|---|---|
| Nausea | Very common | Most frequent; dose-dependent |
| Dizziness | Common | Especially when standing up too quickly |
| Headache | Common | Often mild; relieved with hydration |
| Diarrhea | Common | Self-limiting in most users |
| Insomnia | Uncommon | More likely at higher doses |
| Fatigue | Uncommon | May occur with alcohol use |
These are typically transient and resolve without treatment. Staying hydrated and avoiding alcohol can help reduce risk.
Rare but Serious Side Effects
Though uncommon, some side effects may require medical attention:
- Fainting or sudden loss of consciousness (syncope)
- Low blood pressure when standing (orthostatic hypotension)
- Blurred vision
- Mood swings or irritability
- Rapid heartbeat or arrhythmias
If any of these symptoms occur, stop taking Priligy tablets immediately and contact a healthcare provider.
Note: Fainting episodes are more likely when Priligy is taken with alcohol, recreational drugs, or while dehydrated.
Who Is at Greater Risk of Side Effects?
You may be more likely to experience side effects if you:
- Take the 60 mg dose without medical supervision
- Are dehydrated or skip meals
- Drink alcohol around the time of dosing
- Use Priligy alongside other serotonergic drugs (e.g., SSRIs)
- Have a history of low blood pressure, heart rhythm disorders, or fainting
How to Reduce the Risk of Side Effects
- Always start with Priligy 30mg, unless advised otherwise by your doctor
- Take the tablet with a full glass of water while seated or lying down
- Do not mix with alcohol, sedatives, or recreational drugs
- Avoid driving or operating machinery after the first few doses
- Discuss any side effects with your doctor before increasing the dose
What If I Experience Side Effects?
If you experience mild side effects from Priligy, such as nausea, headache, or light dizziness, there’s usually no cause for alarm. These reactions often resolve on their own within a few hours. In most cases, simple steps like staying hydrated, resting in a quiet environment, and avoiding sudden movements can help reduce discomfort. It’s also a good idea to avoid activities that require focus or coordination—such as driving—until you feel normal again.
You should not take another dose until symptoms have completely resolved, and never increase your dosage without medical advice. If the side effects persist or worsen with repeated use—especially when using Priligy 60mg—consider discussing the possibility of switching to Priligy 30mg with your healthcare provider.
However, if you experience more serious symptoms such as fainting, chest pain, blurred vision, or irregular heartbeat, stop taking the medication immediately and seek professional medical advice. These reactions are rare, but they require prompt attention to ensure your safety.
Summary
| Key Point | Details |
|---|---|
| Most common side effects | Nausea, dizziness, headache, diarrhea |
| Usually mild and short-lived? | Yes |
| Serious risks? | Fainting, blood pressure drop (rare) |
| Risk factors | Alcohol, dehydration, high dose, drug interactions |
| Best way to reduce risk | Start at 30 mg, stay hydrated, avoid alcohol |
Frequently Asked Questions (FAQ)
Can I take Priligy every day?
No, Priligy is not designed for daily use. It is an on-demand medication intended to be taken 1 to 3 hours before sexual activity. Using it daily increases the risk of side effects and is not more effective for premature ejaculation. Always follow your doctor’s instructions regarding dosing frequency.
How long does Priligy last?
The effects of Priligy tablets typically last for 4 to 6 hours after taking the dose. This window allows for improved control over ejaculation during sexual activity without affecting sexual performance beyond that period.
What happens if I take more than one Priligy tablet in 24 hours?
Taking more than one dose in a 24-hour period increases the risk of serious side effects, such as low blood pressure, fainting, nausea, and serotonin syndrome. Always adhere to the recommended dosage — either 30mg or 60mg once per day, never both.
Can Priligy be used with Viagra or other ED medications?
Yes, but only under medical supervision. Combining Priligy with Viagra or other erectile dysfunction drugs (like Cialis or Levitra) may intensify side effects such as dizziness, flushing, or a drop in blood pressure. If you have both premature ejaculation and erectile dysfunction, speak with a doctor to determine the best and safest combination for your needs.
Does Priligy cure premature ejaculation?
No. Priligy does not cure PE, but it is highly effective in managing its symptoms. It provides temporary improvement in ejaculation control, which can significantly enhance sexual confidence and satisfaction. For long-term improvement, behavioral techniques and psychological support may also be recommended.
Is a prescription required to buy Priligy?
In most countries, including the UK, EU, Canada, and Australia, Priligy is a prescription-only medication. However, it is often available via licensed online pharmacies with a valid digital consultation. In the United States, Priligy is not currently FDA-approved, but dapoxetine may be accessible through international services.
Can I take Priligy with food or alcohol?
Priligy can be taken with or without food, although a light meal may reduce nausea. Alcohol should be strictly avoided, as it increases the likelihood of dizziness, fainting, and poor coordination — especially in combination with the medication.
What should I do if I forget to take a dose?
Since Priligy is taken on-demand, there is no set schedule. If you forget to take the tablet before planned sexual activity, simply skip the dose. Do not take it afterward or double the dose later, as this will not improve its effectiveness and may cause adverse effects.
