Managing type 2 diabetes can feel overwhelming, especially with so many treatment options available. Two of the most commonly prescribed medications are Invokana and Jardiance. Both belong to the same class of drugs (SGLT2 inhibitors) and work in similar ways, but they have unique features that make them suitable for different needs. If you’re trying to decide between these two medications, it’s important to understand how they work, their effectiveness, side effects, and other key factors. In this article, we’ll break it all down to help you make an informed decision.
How Do They Work? Understanding the Basics
Before diving into the details, it’s important to understand how Invokana and Jardiance work in your body. Both medications belong to the SGLT2 inhibitor class, which means they target the kidneys to help manage blood sugar levels. However, there are subtle differences in their mechanisms and additional benefits.
- Invokana (Canagliflozin):
- Works by blocking a protein in the kidneys called sodium-glucose co-transporter 2 (SGLT2).
- This prevents the kidneys from reabsorbing glucose, allowing excess sugar to be excreted through urine.
- In addition to lowering blood sugar, Invokana promotes weight loss and has benefits for heart and kidney health.
- Jardiance (Empagliflozin):
- Also blocks the SGLT2 protein in the kidneys, leading to the excretion of excess glucose in urine.
- Like Invokana, it lowers blood sugar, promotes weight loss, and offers cardiovascular and kidney protection.
- Jardiance is particularly known for its strong benefits in reducing the risk of heart failure.
Both Invokana and Jardiance work in the kidneys to remove excess sugar, but they have slight differences in their additional benefits and side effects.
Besides Invokana, Jardiance is often compared to other drug classes such as GLP-1 agonists and DPP-4 inhibitors. If you’re interested in exploring more alternatives, check out this full comparison of Jardiance with other diabetes medications.
How Well Do They Work? Comparing Effectiveness
When it comes to managing diabetes, effectiveness is key. Let’s compare how well Invokana and Jardiance control blood sugar and provide additional health benefits.
- Invokana:
- Lowers HbA1c (long-term blood sugar) by 0.7-1%.
- Promotes weight loss—about 2-4 kg (4-9 lbs) in a year.
- Reduces the risk of cardiovascular events and slows kidney disease progression.
- Jardiance:
- Lowers HbA1c by 0.5-0.7%.
- Promotes weight loss—about 2-3 kg (4-6 lbs) in a year.
- Reduces the risk of heart failure and provides kidney protection.
Invokana is slightly more effective at lowering blood sugar and promoting weight loss, while Jardiance has a stronger focus on heart failure prevention.
What Are the Side Effects? Weighing the Risks
All medications come with potential side effects, and understanding these risks is crucial for making an informed decision. Let’s take a closer look at what you might experience with Invokana and Jardiance.
- Invokana:
- Common: Increased urination, urinary tract infections (UTIs), and yeast infections (due to sugar being excreted in urine).
- Rare: Diabetic ketoacidosis (a serious condition caused by high acid levels in the blood), dehydration, and a higher risk of lower limb amputations (observed in some studies).
- Use with caution if you have kidney problems or a history of foot ulcers.
- Jardiance:
- Common: Increased urination, UTIs, and yeast infections.
- Rare: Diabetic ketoacidosis or dehydration.
- Generally well-tolerated, with a lower risk of amputations compared to Invokana.
Both medications can cause increased urination and infections, but Invokana has a higher risk of serious side effects like amputations.
How Are They Taken? Administration and Convenience
The way you take these medications can impact your daily life. Let’s compare their administration to help you understand which might be more convenient for you.
- Invokana:
- A pill taken once daily, with or without food.
- No special instructions, making it easy to incorporate into your routine.
- Jardiance:
- Also a pill taken once daily, with or without food.
- Similar to Invokana, it’s convenient and easy to take.
Both Invokana and Jardiance are equally convenient, with no significant differences in administration.
Cost Comparison: What’s More Affordable?
Cost is an important factor for many patients, especially when considering long-term treatment. Let’s compare the prices of Invokana and Jardiance.
- Invokana:
- Costs around $500-$700 per month.
- Insurance may cover it, and patient assistance programs can help reduce costs.
- Jardiance:
- Costs around $500-$700 per month.
- Similar to Invokana, insurance coverage and assistance programs are available.
Both medications are similarly priced, so cost may not be a deciding factor.
Which One is Better? Invokana vs. Jardiance
The answer depends on your individual needs:
- Choose Invokana if:
- You need slightly better blood sugar control and weight loss.
- You don’t have a history of foot ulcers or amputations.
- Choose Jardiance if:
- You’re at risk for heart failure or want stronger cardiovascular protection.
- You’re concerned about the risk of amputations.
Final Thoughts
Both Invokana and Jardiance are effective treatments for type 2 diabetes, but they cater to slightly different needs:
- Invokana is great for blood sugar control and weight loss but carries a higher risk of serious side effects.
- Jardiance offers strong heart and kidney protection with a lower risk of complications.
Talk to your doctor to determine which medication is right for you. They’ll consider your health, lifestyle, and goals to help you make the best choice.
